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Page 1
Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications.
Rovira-Llopis S, Bañuls C, Diaz-Morales N, Hernandez-Mijares A, Rocha M, Victor VM. Rovira-Llopis S, et al. Redox Biol. 2017 Apr;11:637-645. doi: 10.1016/j.redox.2017.01.013. Epub 2017 Jan 16. Redox Biol. 2017. PMID: 28131082 Free PMC article. Review.
Mitochondrial fusion is modulated by different proteins, including mitofusin-1 (MFN1), mitofusin-2 (MFN2) and optic atrophy (OPA-1), while fission is controlled by mitochondrial fission 1 (FIS1), dynamin-related protein 1 (DRP1) and mitochondrial fission factor (MFF …
Mitochondrial fusion is modulated by different proteins, including mitofusin-1 (MFN1), mitofusin-2 (MFN2) and optic atrophy (OPA-1), …
A Link Between Mitochondrial Dysfunction and the Immune Microenvironment of Salivary Glands in Primary Sjogren's Syndrome.
Li N, Li Y, Hu J, Wu Y, Yang J, Fan H, Li L, Luo D, Ye Y, Gao Y, Xu H, Hai W, Jiang L. Li N, et al. Front Immunol. 2022 Mar 14;13:845209. doi: 10.3389/fimmu.2022.845209. eCollection 2022. Front Immunol. 2022. PMID: 35359935 Free PMC article.
Clinical data revealed that the gene expression of fission (Fis1, DRP1, and MFF) and fusion (MFN1, MFN2, and OPA1) was downregulated in pSS samples, consistent with the results from the public validation database. ...
Clinical data revealed that the gene expression of fission (Fis1, DRP1, and MFF) and fusion (MFN1, MFN2, and OPA1) was downreg …
Role of Mitochondrial Dynamics in Heart Diseases.
Tokuyama T, Yanagi S. Tokuyama T, et al. Genes (Basel). 2023 Sep 26;14(10):1876. doi: 10.3390/genes14101876. Genes (Basel). 2023. PMID: 37895224 Free PMC article. Review.
Mitochondria are relatively immobile in the adult heart, but their morphological changes due to mitochondrial morphology factors are critical for cellular functions such as energy production, organelle integrity, and stress response. Mitochondrial fusion proteins, particularly …
Mitochondria are relatively immobile in the adult heart, but their morphological changes due to mitochondrial morphology factors are critica …
The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn2+ trafficking.
Song Y, Liang H, Li G, Ma L, Zhu D, Zhang W, Tong B, Li S, Gao Y, Wu X, Zhang Y, Feng X, Wang K, Yang C. Song Y, et al. Autophagy. 2023 Oct 24:1-21. doi: 10.1080/15548627.2023.2274205. Online ahead of print. Autophagy. 2023. PMID: 37876250
Collectively, our findings highlight a working model whereby the NLRX1-SLC39A7 complex coupled mitochondrial dynamics and mitophagy activity to surveil and target damaged mitochondria for degradation, which determines the beneficial function of the mitochondrial surveillance syst …
Collectively, our findings highlight a working model whereby the NLRX1-SLC39A7 complex coupled mitochondrial dynamics and mitophagy activity …
TRPA1 promotes cisplatin-induced acute kidney injury via regulating the endoplasmic reticulum stress-mitochondrial damage.
Deng F, Zhang H, Zhou W, Ma S, Kang Y, Yang W, Zhao L, Qin W. Deng F, et al. J Transl Med. 2023 Oct 5;21(1):695. doi: 10.1186/s12967-023-04351-9. J Transl Med. 2023. PMID: 37798747 Free PMC article.
RESULT: In vivo and in vitro, HC-030031 reduced cisplatin-induced Scr and BUN level elevations; improved cisplatin-induced renal tissue injury, apoptosis, and mitochondrial dysfunction; elevated the reduced ERS-associated proteins glucose-regulated protein 78 (GRP78), glucose-reg …
RESULT: In vivo and in vitro, HC-030031 reduced cisplatin-induced Scr and BUN level elevations; improved cisplatin-induced renal tissue inju …
The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension: Implications for Dynamin-Related Protein 1 and Mitofusin2 in Hyperproliferative Diseases.
Colpman P, Dasgupta A, Archer SL. Colpman P, et al. Cells. 2023 Jul 20;12(14):1897. doi: 10.3390/cells12141897. Cells. 2023. PMID: 37508561 Free PMC article. Review.
Mitochondrial fission is mediated by the large GTPase, dynamin-related protein 1 (Drp1) which, when activated, translocates to the outer mitochondrial membrane (OMM) where it interacts with binding proteins (Fis1, MFF, MiD49 and MiD51). At a site demarcated by the endoplas …
Mitochondrial fission is mediated by the large GTPase, dynamin-related protein 1 (Drp1) which, when activated, translocates to the outer mit …
New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics.
Wang S, Zhao H, Lin S, Lv Y, Lin Y, Liu Y, Peng R, Jin H. Wang S, et al. Front Endocrinol (Lausanne). 2023 Aug 21;14:1230168. doi: 10.3389/fendo.2023.1230168. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37670891 Free PMC article. Review.
Mitochondrial dynamics include mitochondrial fusion and mitochondrial fission. The former is coordinated by mitofusin-1 (Mfn1), mitofusin-2 (Mfn2), and optic atrophy 1 (Opa1), and the latter is mediated by dynamin related protein 1 (Drp1), mitochondrial fission 1 (Fis1) an …
Mitochondrial dynamics include mitochondrial fusion and mitochondrial fission. The former is coordinated by mitofusin-1 (Mfn1), mitof …
The relevance of mitochondrial morphology for human disease.
Navaratnarajah T, Anand R, Reichert AS, Distelmaier F. Navaratnarajah T, et al. Int J Biochem Cell Biol. 2021 May;134:105951. doi: 10.1016/j.biocel.2021.105951. Epub 2021 Feb 18. Int J Biochem Cell Biol. 2021. PMID: 33610749 Review.
To facilitate these processes several proteins are required to regulate mitochondrial shape and interorganellar communication. These proteins include the classical mitochondrial fusion (MFN1, MFN2, and OPA1) and fission proteins (DRP1, MFF, FIS1, etc.) as well as se …
To facilitate these processes several proteins are required to regulate mitochondrial shape and interorganellar communication. These protein …
Redox Modifications of Proteins of the Mitochondrial Fusion and Fission Machinery.
Wolf C, López Del Amo V, Arndt S, Bueno D, Tenzer S, Hanschmann EM, Berndt C, Methner A. Wolf C, et al. Cells. 2020 Mar 27;9(4):815. doi: 10.3390/cells9040815. Cells. 2020. PMID: 32230997 Free PMC article. Review.
Upon specific stimuli, DRP1 translocates to the mitochondria, where it interacts with its receptors FIS1, MFF, and MID49/51. Another fission factor of clinical relevance is GDAP1. ...We reveal that worms and flies possess only a single mitofusin, which in vertebrates diver …
Upon specific stimuli, DRP1 translocates to the mitochondria, where it interacts with its receptors FIS1, MFF, and MID49/51. Another …
Mitochondrial dynamics and cell death in heart failure.
Marín-García J, Akhmedov AT. Marín-García J, et al. Heart Fail Rev. 2016 Mar;21(2):123-36. doi: 10.1007/s10741-016-9530-2. Heart Fail Rev. 2016. PMID: 26872674 Review.
A shift toward fission leads to mitochondrial fragmentation, while a shift toward fusion results in the formation of enlarged mitochondria and in the fusion of damaged mitochondria with healthy organelles. Mfn1, Mfn2 and OPA1 constitute the core machinery promoting mitocho …
A shift toward fission leads to mitochondrial fragmentation, while a shift toward fusion results in the formation of enlarged mitochondria a …
74 results